Cellular Iron Deficiency Disrupts Thyroid Hormone Regulated Gene Expression in Developing Hippocampal Neurons.

ABSTRACT:

Background

Developing neurons have high thyroid hormone and iron requirements to support their metabolically demanding growth. Early-life iron and thyroid-hormone deficiencies are prevalent and often coexist, and each independently increases risk of permanently impaired neurobehavioral function in children. Early-life dietary iron deficiency reduces thyroid-hormone concentrations and impairs thyroid hormone-responsive gene expression in the neonatal rat brain, but it is unclear whether the effect is cell-intrinsic.

Objectives

This study determined whether neuronal-specific iron deficiency alters thyroid hormone-regulated gene expression in developing neurons.

Methods

Iron deficiency was induced in primary mouse embryonic hippocampal neuron cultures with the iron chela

SUBMITTER: Monko TR 

PROVIDER: S-EPMC10808837 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature