Functional neural networks stratify Parkinson's disease patients across the spectrum of cognitive impairment.

ABSTRACT:

Introduction

Cognitive impairment (CI) is a significant non-motor symptoms in Parkinson's disease (PD) that often precedes the emergence of motor symptoms by several years. Patients with PD hypothetically progress from stages without CI (PD-normal cognition [NC]) to stages with Mild CI (PD-MCI) and PD dementia (PDD). CI symptoms in PD are linked to different brain regions and neural pathways, in addition to being the result of dysfunctional subcortical regions. However, it is still unknown how functional dysregulation correlates to progression during the CI. Neuroimaging techniques hold promise in discriminating CI stages of PD and further contribute to the biomarker formation of CI in PD. In this study, we explore disparities in the clinical assessments and resting-state functiona

SUBMITTER: Hajebrahimi F 

PROVIDER: S-EPMC10808882 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature