Metabolite profiles of medulloblastoma for rapid and non-invasive detection of molecular disease groups.

ABSTRACT:

Background

The malignant childhood brain tumour, medulloblastoma, is classified clinically into molecular groups which guide therapy. DNA-methylation profiling is the current classification 'gold-standard', typically delivered 3-4 weeks post-surgery. Pre-surgery non-invasive diagnostics thus offer significant potential to improve early diagnosis and clinical management. Here, we determine tumour metabolite profiles of the four medulloblastoma groups, assess their diagnostic utility using tumour tissue and potential for non-invasive diagnosis using in vivo magnetic resonance spectroscopy (MRS).

Methods

Metabolite profiles were acquired by high-resolution magic-angle spinning NMR spectroscopy (MAS) from 86 medulloblastomas (from 59 male and 27 female patients), previously clas

SUBMITTER: Kohe S 

PROVIDER: S-EPMC10808898 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature