Adults with metabolically healthy overweight or obesity present more brown adipose tissue and higher thermogenesis than their metabolically unhealthy counterparts.

ABSTRACT:

Background

There is a subset of individuals with overweight/obesity characterized by a lower risk of cardiometabolic complications, the so-called metabolically healthy overweight/obesity (MHOO) phenotype. Despite the relatively higher levels of subcutaneous adipose tissue and lower visceral adipose tissue observed in individuals with MHOO than individuals with metabolically unhealthy overweight/obesity (MUOO), little is known about the differences in brown adipose tissue (BAT).

Methods

This study included 53 young adults (28 women) with a body mass index (BMI) ≥25 kg/m² which were classified as MHOO (n = 34) or MUOO (n = 19). BAT was assessed through a static ¹⁸F-FDG positron emission tomography/computed tomography scan after a 2-h personalized cooling

SUBMITTER: Jurado-Fasoli L 

PROVIDER: S-EPMC10808934 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature