Association between lifetime smoking and cutaneous squamous cell carcinoma: A 2-sample Mendelian randomization study.

ABSTRACT:

Background/purpose

Cutaneous squamous cell carcinoma (cSCC) is one of the most common malignancies worldwide. While several environmental risk factors for cSCC are well established, there is conflicting evidence on cigarette smoking (and its potential causal effect) and cSCC risk. Furthermore, it is unclear if these potential associations represent causal, modifiable risk factors for cSCC development. This study aims to assess the nature of the associations between cigarette smoking traits (smoking initiation, amount smoked, and lifetime smoking exposure) and cSCC risk using two-sample Mendelian randomization analyses.

Methods

Genetic instruments, based on common genetic variants associated with cigarette smoking traits (P < 5 × 10^-8), were derived from pub

SUBMITTER: Lee T 

PROVIDER: S-EPMC10808986 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature