CK1δ/ε inhibition induces ULK1-mediated autophagy in tumorigenesis.

ABSTRACT:

Introduction

Autophagy is an important mechanism of cell homeostasis maintenance. As essential serine/threonine-protein kinases, casein kinase I family members affect tumorigenesis by regulating a variety of cellular progression. However, the mechanism by which they regulate autophagy remains unclear.

Materials and methods

We silenced CK1δ/ε in cancer cells and observed cell morphology, the expression of autophagy-related genes, and its impact on cancer cell growth and viability. By inhibiting CK1δ/ε-induced upregulation of autophagy genes, we profiled the regulatory mechanism of CK1δ/ε on autophagy and cancer cell growth. The impact of CK1δ/ε inhibition on tumor cell growth was also assessed in vivo.

Results

Here, we found that CK1δ/ε played an important role in ULK1

SUBMITTER: Xue VW 

PROVIDER: S-EPMC10808987 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature