Molecular aggregation by hydrogen bonding in cold-crystallization behavior of mixed nucleobases analyzed by temperature-controlled infrared spectroscopy.

ABSTRACT: The cold-crystallization behaviors of dodecyl-substituted nucleobases (adenine, uracil, and thymine) were analyzed. The dodecyl derivative from uracil alone did not exhibit cold crystallization; however, a mixture of adenine and uracil derivatives at a molar ratio of 1 : 1 exhibited cold crystallization. These results are similar to the thermal behavior of dodecyl derivatives of adenine and thymine alone and in mixtures reported in a previous study. Temperature-controlled infrared spectroscopy was used to observe the molecular assembly states of the liquid, supercooled state, and cold-crystallized compounds. Hydrogen-bonded molecular pairs in the high-temperature liquid state, multiple hydrogen-bonded networks in the supercooled state, and reverse Hoogsteen-type complementary hydrogen bond

SUBMITTER: Honda A 

PROVIDER: S-EPMC10808993 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature