A forebrain-hypothalamic ER stress driven circuit mediates hepatic steatosis during obesity.

ABSTRACT:

Objective

Non-alcoholic fatty liver disease (NAFLD) affects 1 in 3 adults and contributes to advanced liver injury and cardiometabolic disease. While recent evidence points to involvement of the brain in NAFLD, the downstream neural circuits and neuronal molecular mechanisms involved in this response, remain unclear. Here, we investigated the role of a unique forebrain-hypothalamic circuit in NAFLD.

Methods

Chemogenetic activation and inhibition of circumventricular subfornical organ (SFO) neurons that project to the paraventricular nucleus of the hypothalamus (PVN; SFO→PVN) in mice were used to study the role of SFO→PVN signaling in NAFLD. Novel scanning electron microscopy techniques, histological approaches, molecular biology techniques, and viral methodologies were furth

SUBMITTER: Blackmore K 

PROVIDER: S-EPMC10809102 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature