Age-related differences in structural and resting-state functional brain network organization across the adult lifespan: A cross-sectional study.

ABSTRACT: We investigated age-related trends in the topology and hierarchical organization of brain structural and functional networks using diffusion-weighted imaging and resting-state fMRI data from a large cohort of healthy aging adults. At the cross-modal level, we explored age-related patterns in the RC involvement of different functional subsystems using a high-resolution functional parcellation. We further assessed age-related differences in the structure-function coupling as well as the network vulnerability to damage to rich club connectivity. Regardless of age, the structural and functional brain networks exhibited a rich club organization and small-world topology. In older individuals, we observed reduced integration and segregation within the frontal-occipital regions and the cerebellum

SUBMITTER: Khalilian M 

PROVIDER: S-EPMC10809105 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature