Polygenic Risk in Families With Spontaneous Coronary Artery Dissection.

ABSTRACT:

Importance

Spontaneous coronary artery dissection (SCAD) is a poorly understood cause of acute coronary syndrome that predominantly affects women. Evidence to date suggests a complex genetic architecture, while a family history is reported for a minority of cases.

Objective

To determine the contribution of rare and common genetic variants to SCAD risk in familial cases, the latter via the comparison of a polygenic risk score (PRS) with those with sporadic SCAD and healthy controls.

Design, setting, and participants

This genetic association study analyzed families with SCAD, individuals with sporadic SCAD, and healthy controls. Genotyping was undertaken for all participants. Participants were recruited between 2017 and 2021. A PRS for SCAD was calculated for all partic

SUBMITTER: Tarr I 

PROVIDER: S-EPMC10809133 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature