Blood DNA methylation signature of diet quality and association with cardiometabolic traits.

ABSTRACT:

Aims

Diet quality might influence cardiometabolic health through epigenetic changes, but this has been little investigated in adults. Our aims were to identify cytosine-phosphate-guanine (CpG) dinucleotides associated with diet quality by conducting an epigenome-wide association study (EWAS) based on blood DNA methylation (DNAm) and to assess how diet-related CpGs associate with inherited susceptibility to cardiometabolic traits: body mass index (BMI), systolic blood pressure (SBP), triglycerides, type 2 diabetes (T2D), and coronary heart disease (CHD).

Methods and results

Meta-EWAS including 5274 participants in four cohorts from Spain, the USA, and the UK. We derived three dietary scores (exposures) to measure adherence to a Mediterranean diet, to a healthy plant-based die

SUBMITTER: Dominguez-Barragan J 

PROVIDER: S-EPMC10809172 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature