Associations of non-alcoholic fatty liver disease and cirrhosis with liver cancer in European and East Asian populations: A Mendelian randomization study.

ABSTRACT:

Background

The positive relationships of non-alcoholic fatty liver disease (NAFLD) and cirrhosis with liver cancer were shown in previous observational studies, while further Mendelian randomization (MR) investigations are needed to confirm the possible causal associations.

Aims

This study aimed to explore whether NAFLD and cirrhosis were causally related to liver cancer using MR in European and East Asian populations.

Methods and results

For European populations, NAFLD data were obtained from a genome-wide meta-analysis (8434 patients and 770 180 controls). The data on chronic elevation of alanine aminotransferase (cALT), a proxy of NAFLD, were derived from Million Veteran Program (68 725 patients and 95 472 controls). Cirrhosis data were collected from two sources:

SUBMITTER: Deng Y 

PROVIDER: S-EPMC10809194 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature