The role of non-genomic actions of progesterone and its membrane receptor agonist in ovarian cancer cell death.

ABSTRACT:

Background

Progesterone therapy is a relatively inexpensive treatment option for endometrial and breast cancers, with few side effects. Two signaling pathways usually mediate the physiological effects of progesterone, namely genomic and non-genomic actions. Genomic action occurs slowly via the nuclear progesterone receptor (PR), whereas the membrane progesterone receptor (mPR) induces rapid non-genomic action.

Aims

We investigated the effects of progesterone and various PR agonists on ovarian cancer cells.

Methods and results

PR expression of six serous ovarian cancer cell lines was examined by western blotting, and mPR expression was examined by reverse transcription-quantitative polymerase chain reaction (RT-qPCR). PR-negative and mPR-positive ovarian cancer cells w

SUBMITTER: Koyanagi T 

PROVIDER: S-EPMC10809274 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature