The exploration of mitochondrial-related features helps to reveal the prognosis and immunotherapy methods of colorectal cancer.

ABSTRACT:

Background

Cancer cell survival, proliferation, and metabolism are all intertwined with mitochondria. However, a complete description of how the features of mitochondria relate to the tumor microenvironment (TME) and immunological landscape of colorectal cancer (CRC) has yet to be made. We performed subgroup analysis on CRC patient data obtained from the databases using non-negative matrix factorization (NMF) clustering. Construct a prognostic model using the mitochondrial-related gene (MRG) risk score, and then compare it to other models for accuracy. Comprehensive analyses of the risk score, in conjunction with the TME and immune landscape, were performed, and the relationship between the model and different types of cell death, radiation and chemotherapy, and drug resistance was

SUBMITTER: Xie YH 

PROVIDER: S-EPMC10809275 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature