MOCCal: A Multiomic CCS Calibrator for Traveling Wave Ion Mobility Mass Spectrometry.

ABSTRACT: Ion mobility mass spectrometry (IM-MS) is a rapid, gas-phase separation technology that can resolve ions on the basis of their size-to-charge and mass-to-charge ratios. Since each class of biomolecule has a unique relationship between size and mass, IM-MS spectra of complex biological samples are organized into trendlines that each contain one type of biomolecule (i.e., lipid, peptide, metabolite). These trendlines can aid in the identification of unknown ions by providing a general classification, while more specific identifications require the conversion of IM arrival times to collision cross section (CCS) values to minimize instrument-to-instrument variability. However, the process of converting IM arrival times to CCS values varies between the different IM devices. Arriva

SUBMITTER: Hynds HM 

PROVIDER: S-EPMC10809277 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature