Liver Disease and Cell Therapy: Advances Made and Remaining Challenges.

ABSTRACT: The limited availability of organs for liver transplantation, the ultimate curative treatment for end stage liver disease, has resulted in a growing and unmet need for alternative therapies. Mesenchymal stromal cells (MSCs) with their broad ranging anti-inflammatory and immunomodulatory properties have therefore emerged as a promising therapeutic agent in treating inflammatory liver disease. Significant strides have been made in exploring their biological activity. Clinical application of MSC has shifted the paradigm from using their regenerative potential to one which harnesses their immunomodulatory properties. Reassuringly, MSCs have been extensively investigated for over 30 years with encouraging efficacy and safety data from translational and early phase clinical studies, but question

SUBMITTER: Khan S 

PROVIDER: S-EPMC10809282 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature