Positive additive interaction effects of age, sex, obesity, and metabolic syndrome on left ventricular dysfunction.

ABSTRACT:

Objective

This study aims to explore the association between metabolic syndrome (MetS) and left ventricular diastolic dysfunction (LVDD) and systolic dysfunction (LVSD), defined by impaired global longitudinal strain (GLS), and assess additive and multiplicative interactions among age, sex, obesity, and MetS regarding LVDD and LVSD.

Methods

We prospectively recruited 5503 participants from the China PEACE (Patient-Centered Evaluative Assessment of Cardiac Events) Million Persons Project with complete echocardiography exam. Multivariable logistic models were used to calculate adjusted odds ratios to evaluate both additive and multiplicative interactions.

Results

The mean age was 56.59 years; 59.4% were women, 46.7% had MetS, 26.6% had left ventricular hypertrophy, 46.3

SUBMITTER: Zhou D 

PROVIDER: S-EPMC10809287 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature