The development of thymol-isatin hybrids as broad-spectrum antibacterial agents with potent anti-MRSA activity.

ABSTRACT: Bacterial resistance toward available therapeutic agents has become a nightmare for the healthcare system, causing significant mortality as well as prolonged hospitalization, thereby needing the urgent attention of research groups working on antimicrobial drug development worldwide. Molecular hybridization is a well-established tool for developing multifunctional compounds to tackle drug resistance. Inspired by the antibacterial profiles of isatin and thymol, along with the efficiency of a triazole linker in molecular hybridization, herein, we report the design, synthesis and antibacterial activity of a novel series of triazole tethered thymol-isatin hybrids. Most of the hybrids exhibited a broad-spectrum antibacterial efficacy against standard human pathogenic as well as clinically isolat

SUBMITTER: Singh A 

PROVIDER: S-EPMC10809352 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature