Recent insights into the functions and mechanisms of antisense RNA: emerging applications in cancer therapy and precision medicine.

ABSTRACT: The antisense RNA molecule is a unique DNA transcript consisting of 19-23 nucleotides, characterized by its complementary nature to mRNA. These antisense RNAs play a crucial role in regulating gene expression at various stages, including replication, transcription, and translation. Additionally, artificial antisense RNAs have demonstrated their ability to effectively modulate gene expression in host cells. Consequently, there has been a substantial increase in research dedicated to investigating the roles of antisense RNAs. These molecules have been found to be influential in various cellular processes, such as X-chromosome inactivation and imprinted silencing in healthy cells. However, it is important to recognize that in cancer cells; aberrantly expressed antisense RNAs can trigger the e

SUBMITTER: Rehman SU 

PROVIDER: S-EPMC10809404 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature