Sirtuin 1-activating derivatives belonging to the anilinopyridine class displaying <i>in vivo</i> cardioprotective activities.

ABSTRACT: Sirtuin 1 (SIRT1) is an enzyme that relies on NAD⁺ cofactor and functions as a deacetylase. It has been associated with various biological and pathological processes, including cancer, diabetes, and cardiovascular diseases. Recent studies have shown that compounds that activate SIRT1 exhibit protective effects on the heart. Consequently, targeting SIRT1 has emerged as a viable approach to treat cardiovascular diseases, leading to the identification of several SIRT1 activators derived from natural or synthetic sources. In this study, we developed anilinopyridine-based SIRT1 activators that displayed significantly greater potency in activating SIRT1 compared to the reference compound resveratrol, as demonstrated in enzymatic assays. In particular, compounds 8 and 10, representativ

SUBMITTER: Bononi G 

PROVIDER: S-EPMC10809423 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature