Circulating metabolic profile in idiopathic pulmonary fibrosis: data from the IPF-PRO Registry.

ABSTRACT:

Background

The circulating metabolome, reflecting underlying cellular processes and disease biology, has not been fully characterized in patients with idiopathic pulmonary fibrosis (IPF). We evaluated whether circulating levels of metabolites correlate with the presence of IPF, with the severity of IPF, or with the risk of clinically relevant outcomes among patients with IPF.

Methods

We analyzed enrollment plasma samples from 300 patients with IPF in the IPF-PRO Registry and 100 individuals without known lung disease using a set of targeted metabolomics and clinical analyte modules. Linear regression was used to compare metabolite and clinical analyte levels between patients with IPF and controls and to determine associations between metabolite levels and measures of disease

SUBMITTER: Summer R 

PROVIDER: S-EPMC10809477 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature