An update of clinical value of circulating tumor DNA in esophageal cancer: a systematic review and meta-analysis.

ABSTRACT:

Background

Esophageal cancer (EC) is a deadly disease with limited therapeutic options. Although circulating tumor DNA (ctDNA) could be a promising tool in this regard, the availiable evidence is limited. We performed a systematic review and meta-analysis to summarize the clinical applicability of the next-generation sequencing (NGS) and droplet digital polymerase chain reaction (ddPCR) technology on the ctDNA detection of the EC and listed the current challenges.

Methods

We systematically searched MEDLINE (via PubMed), Embase (via OVID), ISI Web of Science database and Cochrane Library from January, 2000 to April, 2023. Progression-free survival (PFS) and overall survival (OS) were set as primary outcome endpoints. Pathologic response was evaluated by tumor regression grade

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC10809487 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature