Parental genetically predicted liability for coronary heart disease and risk of adverse pregnancy outcomes: a cohort study.

ABSTRACT:

Background

Adverse pregnancy outcomes (APO) may unmask or exacerbate a woman's underlying risk for coronary heart disease (CHD). We estimated associations of maternal and paternal genetically predicted liability for CHD with lifelong risk of APOs. We hypothesized that associations would be found for women, but not their male partners (negative controls).

Methods

We studied up to 83,969‬ women (and up to 55,568‬ male partners) from the Norwegian Mother, Father and Child Cohort Study or the Trøndelag Health Study with genotyping data and lifetime history of any APO in their pregnancies (1967-2019) in the Medical Birth Registry of Norway (miscarriage, stillbirth, hypertensive disorders of pregnancy, gestational diabetes, small for gestational age, large for gestational age, and

SUBMITTER: Hernaez A 

PROVIDER: S-EPMC10809500 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature