Serum levels of PDGF-CC as a potential biomarker for the diagnosis of Kawasaki disease.

ABSTRACT:

Background

Kawasaki disease (KD) is an acute systemic vasculitis of unknown etiology that predominantly affects children, and no specific diagnostic biomarkers for KD are available. Platelet-derived growth factor CC (PDGF-CC) is a peptide with angiogenic properties that has been amply demonstrated to play a critical role in the cardiovascular system. This study aimed to investigate the serum expression of PDGF-CC in children with KD and to evaluate the ability of PDGF-CC to diagnose KD.

Methods

A total of 96 subjects, including 59 KD patients, 17 febrile controls (FC), and 20 healthy controls (HC), were enrolled. Serum levels of PDGF-CC were measured via enzyme-linked immunosorbent assay. The associations between PDGF-CC and clinical laboratory parameters were investigated b

SUBMITTER: Zhang J 

PROVIDER: S-EPMC10809580 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature