Proteomics for heart failure risk stratification: a systematic review.

ABSTRACT:

Background

Heart failure (HF) is a complex clinical syndrome with persistently high mortality. High-throughput proteomic technologies offer new opportunities to improve HF risk stratification, but their contribution remains to be clearly defined. We aimed to systematically review prognostic studies using high-throughput proteomics to identify protein signatures associated with HF mortality.

Methods

We searched four databases and two clinical trial registries for articles published from 2012 to 2023. HF proteomics studies measuring high numbers of proteins using aptamer or antibody-based affinity platforms on human plasma or serum with outcomes of all-cause or cardiovascular death were included. Two reviewers independently screened articles, extracted data, and assessed the r

SUBMITTER: Kuku KO 

PROVIDER: S-EPMC10809595 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature