A novel and efficient murine model for investigating tendon-to-bone healing.

ABSTRACT:

Background

Tendon-to-bone healing is a critical challenge in sports medicine, with its cellular and molecular mechanisms yet to be explored. An efficient murine model could significantly advance our understanding of this process. However, most existing murine animal models face limitations, including a propensity for bleeding, restricted operational space, and a steep learning curve. Thus, the need for a novel and efficient murine animal model to investigate the cellular and molecular mechanisms of tendon-to-bone healing is becoming increasingly evident.

Methods

In our study, forty-four 9-week-old male C57/BL6 mice underwent transection and reattachment of the Achilles tendon insertion to investigate tendon-to-bone healing. At 2 and 4 weeks postoperatively, mice were killed

SUBMITTER: Xu B 

PROVIDER: S-EPMC10809630 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature