METTL3 promotes osteoblast ribosome biogenesis and alleviates periodontitis.

ABSTRACT:

Background

Periodontitis is a highly prevalent oral disease characterized by bacterium-induced periodontal inflammation and alveolar bone destruction. Osteoblast function is impaired in periodontitis with a global proteome change. METTL3 is the pivotal methyltransferase of N⁶-methyladenosine (m⁶A) that is recently proved to exert a crucial role in osteoblast differentiation. This study aims to investigate the role of METTL3 in osteoblast ribosome biogenesis in periodontitis progression.

Results

METTL3 was knocked down in osteoblasts, and the downregulated genes were enriched in ribosome and translation. METTL3 knockdown inhibited ribosome biogenesis and oxidative phosphorylation in LPS-stimulated osteoblasts, whereas METTL3 overexpression facilitated ri

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC10809637 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature