Selective Sensing of DNA Nucleobases with Angular Discrimination.

ABSTRACT: The fast and precise selective sensing of DNA nucleobases is a long-pursued method that can lead to huge advances in the field of genomics and have an impact on aspects such as the prevention of diseases, health enhancement, and, in general, all types of medical treatments. We present here a new type of nanoscale sensor based on carbon nanotubes with a specific geometry that can discriminate the type of nucleobase and also its angle of orientation. The proper differentiation of nucleobases is essential to clearly sequence DNA chains, while angular discrimination is key to improving the sensing selectivity. We perform first-principle and quantum transport simulations to calculate the transmission, conductance, and current of the nanotube-based nanoscale sensor in the presence of the four nu

SUBMITTER: Algharagholy LA 

PROVIDER: S-EPMC10809688 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature