Cyclic-di-AMP confers an invasive phenotype on Escherichia coli through elongation of flagellin filaments.

ABSTRACT:

Background

Adherent-invasive Escherichia coli (AIEC) is isolated from patients with Crohn's disease (CD). AIEC can invade the intestinal epithelium, suggesting that it is involved in the development and pathogenesis of CD. However, the mechanism by which AIEC acquired the invasive phenotype remains unknown.

Results

This study was designed to examine the mechanisms of AIEC invasiveness. We found that the flagellin (fliC) expression in AIEC was two-fold higher than that in non-AIEC strains, and this overexpression induced the formation of long-filament flagellin. Deletion of fliC in the AIEC LF82 strain resulted in the disappearance of flagellar filaments and attenuated the motility and invasive ability of the bacterium, suggesting that the formation of long filament flagellin

SUBMITTER: Tanaka R 

PROVIDER: S-EPMC10809763 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature