Genetic Predisposition of Atherosclerotic Cardiovascular Disease in Ancient Human Remains.

ABSTRACT:

Background

Several computed tomographic studies have shown the presence of atherosclerosis in ancient human remains. However, while it is important to understand the development of atherosclerotic cardiovascular disease (ASCVD), genetic data concerning the prevalence of the disease-associated single nucleotide polymorphisms (SNPs) in our ancestors are scarce.

Objective

For a better understanding of the role of genetics in the evolution of ASCVD, we applied an enrichment capture sequencing approach to mummified human remains from different geographic regions and time periods.

Methods

Twenty-two mummified individuals were analyzed for their genetic predisposition of ASCVD. Next-generation sequencing methods were applied to ancient DNA (aDNA) samples, including a novel e

SUBMITTER: Wurst C 

PROVIDER: S-EPMC10809863 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature