Association between aluminum and iron exposure in maternal blood and umbilical cord blood and congenital heart defects in children.

ABSTRACT:

Background

Congenital heart disease (CHDs) is the major cause of mortality from birth defects, affecting up to 1% of live births worldwide. However, the relationship between aluminum (Al) and iron (Fe) levels and the risk of CHDs has yielded inconsistent results.

Methods

We conducted a pair-matched case-control study that included 97 CHDs and 194 non-CHDs to investigate the association and interaction between Al/Fe exposure and the risk of CHDs in a birth cohort study in Lanzhou, China.

Results

Higher concentrations of cord blood Al were associated with a greater risk of total CHDs (aOR = 2.826, 95% CI [1.009-7.266]) and isolated CHDs (aOR = 10.713, 95% CI [1.017-112.851]) compared to the lowest Al level. Both in maternal blood and cord blood, a significant dose-effec

SUBMITTER: Li J 

PROVIDER: S-EPMC10809980 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature