Prognostic value of circulating plasma cells detected by flow cytometry in newly diagnosed multiple myeloma patients: a systematic review and meta-analysis.

ABSTRACT:

Objectives

Multiple myeloma (MM) is a malignant plasma cell disorder. The most widely accepted staging system for MM is the revised International Staging System based on cytogenetic and clinical biomarkers. The circulating clonal plasma cells (CPCs) were reported to have potential prognostic impact on MM. Among various diagnostic approaches, multiparametric flow cytometry (FCM) offers heightened sensitivity, minimal invasiveness and reproducibility. We conducted a meta-analysis to evaluate the prognostic value of quantifying CPCs via FCM in newly diagnosed symptomatic MM (NDMM) patients.

Design

Systematic review and meta-analysis.

Data source

PubMed, Web of Science, Embase and references of included studies.

Eligibility criteria for selecting studies

We include

SUBMITTER: Liu X 

PROVIDER: S-EPMC10810043 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature