A Comparison of In Vitro Studies between Cobalt(III) and Copper(II) Complexes with Thiosemicarbazone Ligands to Treat Triple Negative Breast Cancer.

ABSTRACT: Metal complexes have gained significant attention as potential anti-cancer agents. The anti-cancer activity of [Co(phen)₂(MeATSC)](NO₃)₃•1.5H₂O•C₂H₅OH 1 (where phen = 1,10-phenanthroline and MeATSC = 9-anthraldehyde-N(4)-methylthiosemicarbazone) and [Cu(acetylethTSC)Cl]Cl•0.25C₂H₅OH 2 (where acetylethTSC = (E)-N-ethyl-2-[1-(thiazol-2-yl)ethylidene]hydrazinecarbothioamide) was investigated by analyzing DNA cleavage activity. The cytotoxic effect was analyzed using CCK-8 viability assay. The activities of caspase 3/7, 9, and 1, reactive oxygen species (ROS) production, cell cycle arrest, and mitochondrial function were further analyzed to study the cell death mechanisms. Comple

SUBMITTER: Alajroush DR 

PROVIDER: S-EPMC10810091 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature