Astrocyte Reactivity and Neurodegeneration in the Female Rat Brain Following Alcohol Dependence.

ABSTRACT: Recent evidence suggests that alcohol use disorder (AUD) may manifest itself differently in women compared to men. Women experience AUDs on an accelerated timeline and may have certain regional vulnerabilities. In male rats, neuronal cell death and astrocyte reactivity are noted following induction of alcohol dependence in an animal model of an AUD. However, the regional and temporal patterns of neurodegeneration and astrocyte reactivity have yet to be fully examined in females using this model. Therefore, adult female rats were exposed to a 4-day binge model of alcohol dependence followed by different periods of abstinence. Histological markers for FluoroJade B, a label of degenerating neurons, and vimentin, a marker for reactive astrocytes, were utilized. The expression of these markers

SUBMITTER: Guerin SP 

PROVIDER: S-EPMC10810177 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature