Glucocorticoid-Induced Ocular Hypertension: Origins and New Approaches to Minimize.

ABSTRACT:

Introduction

Glucocorticoids (GCs) have unique actions in their combined anti-inflammatory and immunosuppressive activities and are among the most commonly-prescribed drugs, particularly for inflammatory conditions. They are often used clinically to treat inflammatory eye diseases like uveitis, optic neuritis, conjunctivitis, keratitis and others, but are often accompanied by side effects, like ocular hypertension that can be vision threatening.

Areas covered

The review will focus on the complex molecular mechanism of action of GCs that involve both transactivation and transrepression and their use therapeutically that can cause significant systemic side effects, particularly ocular hypertension that can lead to glaucoma.

Expert opinion

While we are still unclear as t

SUBMITTER: Yorio T 

PROVIDER: S-EPMC10810227 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature