Function and dysfunction of the dystonia network: an exploration of neural circuits that underlie the acquired and isolated dystonias.

ABSTRACT: Dystonia is a highly prevalent movement disorder that can manifest at any time across the lifespan. An increasing number of investigations have tied this disorder to dysfunction of a broad "dystonia network" encompassing the cerebellum, thalamus, basal ganglia, and cortex. However, pinpointing how dysfunction of the various anatomic components of the network produces the wide variety of dystonia presentations across etiologies remains a difficult problem. In this review, a discussion of functional network findings in non-mendelian etiologies of dystonia is undertaken. Initially acquired etiologies of dystonia and how lesion location leads to alterations in network function are explored, first through an examination of cerebral palsy, in which early brain injury may lead to dystonic/dyskine

SUBMITTER: Gill JS 

PROVIDER: S-EPMC10810232 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature