Population-attributable risk of modifiable lifestyle factors to hepatocellular carcinoma: The multi-ethnic cohort.

ABSTRACT:

Background and aims

Lifestyle factors are well associated with risk of hepatocellular carcinoma (HCC). However, the impact of reducing adverse lifestyle behaviours on population-level burden of HCC is uncertain.

Methods

We conducted prospective analysis of the population-based multi-ethnic cohort (MEC) with linkage to cancer registries. The association of lifestyle factors (smoking, alcohol, diet quality assessed by alternate Mediterranean diet score, coffee drinking, physical activity and body mass index) with HCC incidence was examined using Cox regression. Population-attributable risk (PAR, %) for the overall, lean and overweight/obese populations was determined.

Results

A total of 753 incident cases of HCC were identified in 181,346 participants over median follow

SUBMITTER: Zhou K 

PROVIDER: S-EPMC10810233 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature