Hi-BDiSCO: folding 3D mesoscale genome structures from Hi-C data using brownian dynamics.

ABSTRACT: The structure and dynamics of the eukaryotic genome are intimately linked to gene regulation and transcriptional activity. Many chromosome conformation capture experiments like Hi-C have been developed to detect genome-wide contact frequencies and quantify loop/compartment structures for different cellular contexts and time-dependent processes. However, a full understanding of these events requires explicit descriptions of representative chromatin and chromosome configurations. With the exponentially growing amount of data from Hi-C experiments, many methods for deriving 3D structures from contact frequency data have been developed. Yet, most reconstruction methods use polymer models with low resolution to predict overall genome structure. Here we present a Brownian Dynamics (BD) approach

SUBMITTER: Li Z 

PROVIDER: S-EPMC10810283 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature