Sex differences in the effects of brown adipocyte CD47 deficiency on age-related weight change and glucose homeostasis.

ABSTRACT: Our previous studies demonstrated that mice with global CD47 deficiency are lean and resistant to diet or aging-associated obesity and metabolic complications. This protective effect is partially through modulating brown fat function. To definitively determine the role of brown fat CD47 in age-related metabolic homeostasis, inducible brown adipocyte-specific cd47 deficient mice were generated by crossbreeding cd47 floxed mice with UCP1-Cre^ERT2 mice and characterized in this study. Efficient knockdown of CD47 in brown fat was achieved in both male and female mice through tamoxifen administration. Intriguingly, our findings indicated that male mice lacking CD47 in brown fat displayed a notable reduction in body weight starting at 23 weeks of age when housed at a temperature of 22 

SUBMITTER: Li D 

PROVIDER: S-EPMC10810338 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature