Frailty and Cardiovascular Outcomes in Adults With CKD: Findings From the Chronic Renal Insufficiency Cohort (CRIC) Study.

ABSTRACT:

Rationale & objective

Frailty is common in individuals with chronic kidney disease (CKD) and increases the risk of adverse outcomes in adults with kidney failure requiring dialysis. However, this relationship has not been thoroughly evaluated among those with non-dialysis-dependent CKD.

Study design

Prospective cohort study.

Setting & participants

2,539 adults in the Chronic Renal Insufficiency Cohort Study.

Exposure

Frailty status assessed using 5 criteria: slow gait speed, muscle weakness, low physical activity, exhaustion, and unintentional weight loss.

Outcome

Atherosclerotic events, incident heart failure, all-cause death, and cardiovascular death.

Analytical approach

Cause-specific hazards models.

Results

At study entry, the participa

SUBMITTER: Hannan M 

PROVIDER: S-EPMC10810341 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature