Lhx3/4 initiates a cardiopharyngeal-specific transcriptional program in response to widespread FGF signaling.

ABSTRACT: Individual signaling pathways, such as fibroblast growth factors (FGFs), can regulate a plethora of inductive events. According to current paradigms, signal-dependent transcription factors (TFs), such as FGF/MapK-activated Ets family factors, partner with lineage-determining factors to achieve regulatory specificity. However, many aspects of this model have not been rigorously investigated. One key question relates to whether lineage-determining factors dictate lineage-specific responses to inductive signals or facilitate these responses in collaboration with other inputs. We utilize the chordate model Ciona robusta to investigate mechanisms generating lineage-specific induction. Previous studies in C. robusta have shown that cardiopharyngeal progenitor cells are specified through the comb

SUBMITTER: Pickett CJ 

PROVIDER: S-EPMC10810493 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature