Implications for TB control among migrants in large cities in China: a prospective population-based genomic epidemiology study in Shenzhen.

ABSTRACT: Internal migrants are a challenge for TB control in large Chinese cities and understanding this epidemiology is crucial for designing effective control and prevention strategies. We conducted a prospective genomic epidemiological study of culture-positive TB patients diagnosed between June 1, 2018 and May 31, 2021 in the Longhua District of Shenzhen. Treatment status was obtained from local and national TB registries and all isolates were sequenced. Genomic clusters were defined as strains differing by ≤12 SNPs. Risk factors for clustering were identified with multivariable analysis and then Bayesian models and TransPhylo were used to infer the timing of transmission within clusters. Of the 2277 culture-positive patients, 70.1% (1596/2277) were migrants: 72.1% (1043/1446) of the migrants p

SUBMITTER: Mijiti P 

PROVIDER: S-EPMC10810669 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature