Cost-effectiveness of Low-complexity Screening Tests in Community-based Case-finding for Tuberculosis.

ABSTRACT:

Introduction

In high-burden settings, low-complexity screening tests for tuberculosis (TB) could expand the reach of community-based case-finding efforts. The potential costs and cost-effectiveness of approaches incorporating these tests are poorly understood.

Methods

We developed a microsimulation model assessing 3 approaches to community-based case-finding in hypothetical populations (India-, South Africa-, The Philippines-, Uganda-, and Vietnam-like settings) with TB prevalence 4 times that of national estimates: (1) screening with a point-of-care C-reactive protein (CRP) test, (2) screening with a more sensitive "Hypothetical Screening test" (95% sensitive for Xpert Ultra-positive TB, 70% specificity; equipment/labor costs similar to Xpert Ultra, but using a $2 cartridge

SUBMITTER: Brummer LE 

PROVIDER: S-EPMC10810711 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature