Late effects of high-dose methotrexate in childhood cancer survivors: a Swiss single centre observational study.

ABSTRACT:

Importance

Childhood cancer survivors (CCS) are at risk for late effects of different organ systems. The currently available screening recommendations for those treated with high-dose methotrexate (HD-MTX) are not uniform and the available literature is limited.

Objective

We aim to assess the prevalence and severity of late effects in CCS treated with HD-MTX at a single centre in Switzerland. We focus on organ systems defined at risk by the long-term follow-up care guidelines of the children's oncology group (COG), because this guideline has a holistic approach, is evidence based, and up to date.

Methods

We used the modified Common Terminology Criteria for Adverse Events (CTCAE) to assess late effects in 15 different organ systems. Eligible were CCS diagnosed with can

SUBMITTER: Brunold K 

PROVIDER: S-EPMC10810765 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature