ERCC1 abundance is an indicator of DNA repair-apoptosis decision upon DNA damage.

ABSTRACT: DNA repair is essential for successful propagation of genetic material and fidelity of transcription. Nucleotide excision repair (NER) is one of the earliest DNA repair mechanisms, functionally conserved from bacteria to human. The fact that number of NER genes vary significantly between prokaryotes and metazoans gives the insight that NER proteins have evolved to acquire additional functions to combat challenges associated with a diploid genome, including being involved in the decision between DNA repair and apoptosis. However, no direct association between apoptosis and NER proteins has been shown to date. In this study, we induced apoptosis with a variety of agents, including oxaliplatin, doxorubicin and TRAIL, and observed changes in the abundance and molecular weight of NER complex pr

SUBMITTER: Erdemir Sayan S 

PROVIDER: S-EPMC10810800 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature