Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) deletion in myeloid cells augments cholestatic liver injury.

ABSTRACT: Ductular reactive (DR) cells exacerbate cholestatic liver injury and fibrosis. Herein, we posit that tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) emanates from recruited macrophages and restrains DR cell expansion, thereby limiting cholestatic liver injury. Wild type (WT), Trail^fl/fl and myeloid-specific Trail deleted (Trail^Δmye) C57BL/6 mice were exposed to DDC diet-induced cholestatic liver injury, which induced hepatomegaly and liver injury as compared to control diet-fed mice. However, parameters of liver injury, fibrosis, and inflammation were all increased in the Trail^Δmye mice as compared to the WT and Trail^fl/fl mice. High dimensional mass cytometry indicated that cholestasis resulted in increased hepatic recruitment of

SUBMITTER: Krishnan A 

PROVIDER: S-EPMC10810846 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature