Advancements in the Genetics of Spontaneous Coronary Artery Dissection.

ABSTRACT:

Purpose of review

Spontaneous coronary artery dissection (SCAD) is a significant cause of acute myocardial infarction that is increasingly recognized in young and middle-aged women. The etiology of SCAD is likely multifactorial and may include the interaction of environmental and individual factors. Here, we summarize the current understanding of the genetic factors contributing to the development of SCAD.

Recent findings

The molecular findings underlying SCAD have been demonstrated to include a combination of rare DNA sequence variants with large effects, common variants contributing to a complex genetic architecture, and variants with intermediate impact. The genes associated with SCAD highlight the role of arterial cells and their extracellular matrix in the pathogenesis

SUBMITTER: Katz AE 

PROVIDER: S-EPMC10810930 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature