Identification of gene signatures and molecular mechanisms underlying the mutual exclusion between psoriasis and leprosy.

ABSTRACT: Leprosy and psoriasis rarely coexist, the specific molecular mechanisms underlying their mutual exclusion have not been extensively investigated. This study aimed to reveal the underlying mechanism responsible for the mutual exclusion between psoriasis and leprosy. We obtained leprosy and psoriasis data from ArrayExpress and GEO database. Differential expression analysis was conducted separately on the leprosy and psoriasis using DEseq2. Differentially expressed genes (DEGs) with opposite expression patterns in psoriasis and leprosy were identified, which could potentially involve in their mutual exclusion. Enrichment analysis was performed on these candidate mutually exclusive genes, and a protein-protein interaction (PPI) network was constructed to identify hub genes. The expression of t

SUBMITTER: Lu YW 

PROVIDER: S-EPMC10810956 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature