A curated multivariate approach to study efficacy and optimisation of a prototype vaccine against teladorsagiasis in sheep.

ABSTRACT: This work discusses and demonstrates the novel use of multivariate analysis and data dimensionality reduction techniques to handle the variety and complexity of data generated in efficacy trials for the development of a prototype vaccine to protect sheep against the Teladorsagia circumcincta nematode. A curated collection of data dimension reduction and visualisation techniques, in conjunction with sensible statistical modelling and testing which explicitly model key features of the data, offers a synthetic view of the relationships between the multiple biological parameters measured. New biological insight is gained into the patterns and associations involving antigen-specific antibody levels, antibody avidity and parasitological parameters of efficacy that is not achievable by standard s

SUBMITTER: Palarea-Albaladejo J 

PROVIDER: S-EPMC10810991 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature