Immunogenicity and efficacy of an oral live-attenuated vaccine for bovine Johne's disease.

ABSTRACT: Mycobacterium avium subsp. paratuberculosis (MAP), the etiological agent of Johne's disease (JD) in ruminants, establishes a prolonged and often lifelong enteric infection. The implementation of control measures for bovine JD has faced obstacles due to the considerable expenses involved in disease surveillance and hindered by unreliable and inadequate diagnostic tests, emphasizing the need for an effective vaccine that can stimulate mucosal immunity in the gastrointestinal tract. Previous investigations have demonstrated that deletion of the BacA gene in MAP produces an attenuated strain that can transiently colonize the calf small intestine while retaining its capacity to stimulate systemic immune responses similar to wildtype MAP strains. This study assessed the effi

SUBMITTER: Eshraghisamani R 

PROVIDER: S-EPMC10810994 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature